Continuing Medical Education
ADHD Clinical Trials in Children & Adolescents
An online medical-education quiz translating phase III trial data
Note. This is a de-identified work sample. Brand and product names have been redacted to respect client confidentiality; the clinical substance and references are preserved.
A recurring challenge in medical education is helping clinicians extract what matters from dense clinical-trial reports. This online quiz was designed to do exactly that, turning the design and results of phase III ADHD trials in children and adolescents into a short series of true/false items, each followed by a referenced rationale.
Sample item: primary endpoint
True or False? Change from baseline (CFB) at end of study (EOS) in the ADHD-RS-5 Total score was the primary endpoint in the phase III pediatric and adolescent trials.
Answer: True. CFB at EOS in the ADHD-RS-5 Total score was the primary endpoint. Additional measures included Clinical Global Impression–Improvement (CGI-I) scores, the Conners 3–Parent Short Form Composite T-score, and the Weiss Functional Impairment Rating Scale–Parent (WFIRS-P) Total average. Laboratory tests, vital signs, physical examinations, ECGs, and adverse events were monitored for safety.
Sample item: efficacy outcomes
True or False? Compared with placebo, reductions in inattention and hyperactivity/impulsivity symptom scores were not observed in children and adolescents.
Answer: False. In both children and adolescents, statistically significant improvements at EOS were seen in ADHD-RS-5 Total scores and in the Inattention and Hyperactivity/Impulsivity subscales versus placebo. In children (ages 6–11), significant improvements were also measured in CGI-I, the Conners 3–PS Composite T-score, and WFIRS-P Total average; in adolescents (ages 12–17), CGI-I scores improved significantly versus placebo.
Why this format works
Short, well-constructed knowledge checks turn passive reading into active recall. Pairing each answer with a concise, referenced rationale reinforces the underlying evidence and keeps the education accurate, balanced, and compliant.
Written by Heba Azzam as a medical writer. Brand details redacted; references on file in the original deliverable.